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HSF1 DNA-binding capacity is not negatively affected by ageing. Tissues were taken from 3- and 22-month-old mice 2 h after treatment with HSP990 (12 mg/kg) or vehicle. Levels of HSF1 bound to HS promoters as determined by ChIP. Solid line represents the IgG control values. Data are the mean ± SEM. 4<n < 8/group. Muscle, quadriceps; mth, months; A.U., arbitrary units.
