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. 2014 Feb 20;23(14):3716–3732. doi: 10.1093/hmg/ddu080

Figure 1.

Figure 1.

MB improved behavioral deficits in P301S mice. (A) Number of rearings and (B) distance moved in the open field in WT mice fed a control diet (Wt Cont, n = 10), WT mice fed the MB low dose diet (Wt MB low, n = 14), WT mice fed the MB high dose diet (Wt MB High, n = 15), P301S mice fed a control diet (P301S Cont, n = 11), P301S mice fed the MB low dose diet (P301S MB Low, n = 15) and P301S mice fed the MB high dose diet (P301S MB High, n = 13). P301S mice fed a control diet were significantly more hyperactive in the open field test when compared with WT mice fed a control diet (Fisher's PLSD, *P < 0.05). MB significantly reduced hyperactivity in P301S mice fed the MB low dose diet when compared with P301S mice fed a control diet (Fisher's PLSD, †P < 0.05). (C) Time spent in the open arms and (D) total number of entries between arms in the elevated plus maze in Wt Cont (n = 9), Wt MB Low (n = 14), Wt MB High (n = 15), P301S Cont (n = 10), P301S MB Low (n = 15) and P301S MB High (n = 13). P301S mice fed a control diet were significantly dis-inhibited and significantly more hyperactive in the elevated plus maze when compared with WT mice fed a control diet (Fisher's PLSD, *P < 0.05). MB significantly reduced behavioral abnormalities in P301S mice fed the MB low dose diet when compared with P301S mice fed a control diet (Fisher's PLSD, †P < 0.05). (E) Percent time freezing on day 1 and (F) day 2 of the contextual fear conditioning test in Wt Cont (n = 10), Wt MB Low (n = 14), Wt MB High (n = 15), P301S Cont (n = 9), P301S MB Low (n = 14) and P301S MB High (n = 12). There were no significant differences between groups on day 1 of testing. P301S mice fed a control diet showed a significant decrease in memory during the retention period on day 2 compared with WT mice fed a control diet (Fisher's PLSD, *P < 0.05). MB significantly increased learning and memory in P301S mice fed the MB low dose diet when compared with P301S mice fed a control diet on day 2 of testing (Fisher's PLSD, †P < 0.05).