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. 2014 Feb 20;23(14):3716–3732. doi: 10.1093/hmg/ddu080

Figure 7.

Figure 7.

MB modulated Nrf2/ARE genes in P301S mice. (A) Nrf2/ARE genes in cerebral cortex and (B) hippocampus of WT mice fed a control diet (Wt Cont, n = 4), WT mice fed the MB low dose diet (Wt MB Low, n = 5), WT mice fed the MB high dose diet (Wt MB High, n = 5), P301S mice fed a control diet (P301S Cont, n = 4), P301S mice fed the MB low dose diet (P301S MB Low, n = 5) and P301S mice fed the MB high dose diet (P301S MB High, n = 5). In the cerebral cortex, MB significantly increased expression of Nrf2, and HO1 in P301S mice fed the MB high dose diet when compared with P301S mice fed a control diet (Fisher's PLSD, ‡P < 0.05) and significantly decreased expression of iNOS in P301S mice fed the MB low dose diet and the MB high dose diet when compared with P301S mice fed a control diet (Fisher's PLSD, †P < 0.05, ‡P < 0.05). In the hippocampus, MB significantly increased expression of Nrf2 in P301S mice fed the MB low dose diet and the MB high dose diet when compared with P301S mice fed a control diet (Fisher's PLSD, †P < 0.05, ‡P < 0.05), and significantly increased expression of HO1 in P301S mice fed the MB low dose diet when compared with P301S mice fed a control diet (Fisher's PLSD, †P < 0.05) and NQO1, Gclc and Gclm in P301S mice fed the MB high dose diet when compared with P301S mice fed a control diet (Fisher's PLSD, ‡P < 0.05). iNOS mRNA levels were significantly increased in the hippocampus of P301S mice fed a control diet when compared with WT mice fed a control diet (Fisher's PLSD, *P < 0.05). MB significantly decreased iNOS expression in hippocampus of P301S mice fed the MB low dose diet when compared with P301S mice fed a control diet (Fisher's PLSD, †P < 0.05). (C) Nrf2 immunoreactivity in P301S Cont, P301S MB Low and P301S MB High. MB increased the apparent Nrf2 immunoreactivity and caused nuclear translocation of Nrf2 in P301S mice fed the MB low dose diet and P301S mice fed the MB high dose diet when compared with P301S mice fed a control diet.