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. 2014 Feb 28;23(14):3779–3791. doi: 10.1093/hmg/ddu091

Figure 5.

Figure 5.

Knockdown of Rbm20 is associated with dysregulation of gene splicing and a limited subset of cardiac genes at d12. (A) Summary of total transcripts analyzed by RNAseq in shRbm20 and control EBs at d12. (B) Barplot for the GO term enrichment analysis for differential genes at Day 12. (C) RNAseq data from shRbm20 and control-derived EBs at d12 (left) and expression profile through in vivo cardiogenesis of the 21 genes differentially expressed in shRbm20 (right). Natural cardiogenesis is represented by nine developmental stages E7.5, to adult stages, and by left (L) and right (R) ventricles when they became distinguishable in the heart, ESC was used as pluripotent stage. Link between differentially expressed genes in shRbm20 cardiomyocytes and cardiac diseases associated. EL, embryonic lethal; IHD, ischemic heart disease; HCM, hypertrophic cardiomyopathy; CHD, congenital heart disease; DCM, dilated cardiomyopathy.