Table 1.

Percentage unbound (free) drug concentrations of naproxen, warfarin, and digitoxin in various albumin solutions

	Naproxen 0.1 mmol/L	Warfarin 0.05 mmol/L	Digitoxin 0.02 mmol/L
Human serum	0.07 (0.02)%	0.7 (0.2)%	4.9 (0.2)%
Sigma albumin	0.04 (0.01)%	1.1 (0.2)%	5.1 (0.4)%
Baxter/Immuno	2.77 (0.09)%*	4.1 (0.2)%*	11.1 (0.3)%*
Pharmacia & Upjohn	3.15 (0.17)%*	5.2 (0.5)%*	11.5 (0.4)%*
Octapharma	2.61 (0.10)%*	4.8 (0.3)%*	10.0 (0.4)%*

Percent free drug concentrations of naproxen, warfarin, and digitoxin calculated from the results obtained by ultrafiltration of the albumin solutions and human serum. The solutions were diluted to the final albumin concentration of 0.615 mmol/L. Values are means (SDs) of five separate experiments. * p < 0.05 compared with Sigma albumin and human serum.