Table 1. Candidate genes selected based on the fold change value in gene expression, CpG status and literature.
| Gene Symbol | Gene Name |
Genomic Coordinates | Log.FC.A549.vs.DDP1 | FC.A549.vs DDP2 | The main function |
|---|---|---|---|---|---|
| S100P | S100 calcium binding protein P | chr4:6698819–6698878 | 10.9517 | 11465.41 | Cell cycle progression and differentiation23,24 |
| GDA | guanine deaminase | chr9:74764241–74764903 | 10.10189 | 21100.65 | Microtubule assembly37 |
| WISP2 | WNT1 inducible signaling pathway protein 2 | chr20:43356347–43356406 | 9.287682 | 852.17 | Downstream of the WNT1 signaling pathway that is relevant to malignant transformation25,26 |
| LOXL1 | lysyl oxidase-like 1 | chr15:74241855–74241914 | 7.908342 | 411.57 | Formation of crosslinks in collagens and elastin27,28 |
| TIMP4 | Tissue inhibitor of metallopeptidase 4 | chr3:12194787–12194728 | 7.575363 | 200.16 | Remodeling of the Extracellular matrix29 |
| ICAM1 | intercellular adhesion molecule 1 | chr19:10396298–10396358 | 7.333666 | 119.84 | cell adhesion30,31 |
| CLMP | CXADR-like membrane protein | chr11:122943288–122943229 | 7.327258 | 2328.20 | A component of epithelial tight junctions38 |
| HSPB8 | heat shock 22kDa protein 8 | chr12:118100934–118101264 | 7.275802 | 1704.34 | regulation of cell proliferation, apoptosis, and carcinogenesis32 |
| GAS1 | growth arrest-specific 1 | chr9:89559953–89559894 | 6.892795 | 175.46 | Growth suppression33,34 |
| BMP2 | bone morphogenetic protein 2 | chr20:6760810–6760869 | 5.316618 | 55.52 | Cell growth, differentiation, migration and invasion35 |
1 Data from Agilent SurePrint G3 Human Gene Expression microarray; 2Data from customized PCR array; FC, fold change.