Fig. 2.

Cardiac CBR1, CBR3, AKR1A1, AKR1C3, and AKR7A2 protein expression in samples from donors with- and without- DS. Each symbol depicts the average of individual samples. Horizontal lines indicate group means. Samples and standards for calibration curves were analyzed in duplicates for CBR3 and in triplicates for CBR1, AKR1A1, AKR1C3, AKR7A2. Samples exhibiting protein levels below the LOQs were excluded (Supplemental Fig. 1). Insets show representative immunoblots for recombinant standards (left) and cytosolic CBRs-AKRs plus GADPH (right). Relative abundance of cardiac CBRs and AKRs proteins in donors without- (f) and with- DS (g).