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. 2014 Apr 2;4(6):1059–1069. doi: 10.1534/g3.114.011205

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Copyright © 2014 Leung et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution Unported License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Genetic interaction profiles changed in response to DNA-damaging agents. (A) Pearson’s correlation revealed that the genetic interaction profiles of RTT107 were more similar to one another regardless of the drug condition, whereas SLX4 and HRQ1 were more similar to one another. (B) Density plots of the S-scores for each query gene showed a broader distribution of S-scores for RTT107 than SLX4 or HRQ1. (C) rtt107∆ mutants were more sensitive to DNA-damaging agents than slx4∆ or hrq1∆. 10-fold serial dilutions of the indicated strains were plated onto media containing the indicated drugs.