Figure 5.

BayK-induced changes in motor disability grade in WT and Ca_v1.2DHP–/– mice. WT (closed circles, n = 5) or Ca_v1.2DHP–/– (open circles, n = 5) mice were injected subcutaneously with 2 mg/kg BayK and placed singly in 20 cm ∞30 cm clear plastic cages. They were then observed for 1 minute each at 5-minute intervals. Motor disability was rated at each timepoint on a 4-point scale according to Jinnah et al. (8). No motor symptoms or abnormal behavior were observed after injection of vehicle alone.