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. 2014 Jan 23;4(6):957–971. doi: 10.1534/g3.113.009936

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Copyright © 2014 Lawless et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution Unported License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Network analysis of differentially expressed (DE) genes. InnateDB was used to generate a network of experimentally supported molecular interactions that have been annotated to occur directly between the DE genes and their encoded products. (A) The top 20 CytoHubba-predicted network hubs and their interactors. Overlain on the network is gene expression data from MIMs at 36 hpi (red = upregulated; green = downregulated). The top 20 hubs were highly enriched for roles in innate immunity. (B) The high-scoring DE subnetwork identified in the larger network using jActiveModules. This module was highly enriched for several innate immune relevant pathways.