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. 2014 Jan 23;4(6):957–971. doi: 10.1534/g3.113.009936

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Copyright © 2014 Lawless et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution Unported License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Visualization of miRNA targets. (A) Two-dimensional cluster analysis and heatmap visualization of the miRNA/mRNA expression correlation data matrix after filtering by predicted miRNA-targets and correlation significance. The primary split in the upper hierarchical dendrogram largely aligns with the upregulated miRNA (red) and downregulated miRNA (green). miRNA/mRNA target expression correlations are colored based on increasing significance (light blue to blue) with nontarget/nonsignificant correlations masked (gray). (B) A network representation of the predicted targets (circular nodes) of downregulated miRNAs (green arrows). Red circles = upregulated in MIM mRNA expression data at 36 and/or 48 hpi. Larger circular nodes represent those genes that have been annotated by InnateDB to have a role in innate immunity. (C) A network representation of the predicted targets (circular nodes) of upregulated miRNAs (red arrows). Green circles = downregulated in MIM mRNA expression data at 36 and/or 48 hpi. Note that the predicted targets of downregulated but not upregulated miRNAs are highly enriched for roles in innate immunity.