Table 2.
Clinical parameter | Overall clinical score | ||
---|---|---|---|
Treated (mean ± SD) | Control (mean ± SD) | p value$ | |
Intensive treatment phase | |||
W0 | 30.8 ± 12.3 | ||
W1 | 18.3 ± 9.6 | ||
W2 | 9.6 ± 8.4 | ||
% Change W1 vs. W0 | −40.5**** | ||
% Change W2 vs. W0 | −68.8**** | ||
Maintenance phase | |||
W2 | 9.6 ± 8.3 | 9.7 ± 8.7 | |
W6 | 5.9 ± 6.3 | 16.3 ± 11.4 | |
% Change W6 vs. W0 | −79.9**** | −49.2**** | 0.0407 |
% Change W6 vs. W2 | −37.8* | +68.4*** | <0.0001 |
W10 | 5.15 ± 6.6 | 21.60 ± 12.2 | |
% Change W10 vs. W0 | −82.6**** | −32.5**** | <0.0001 |
% Change W10 vs. W2 | −46.0** | +123.7**** | <0.0001 |
Intragroup comparison of mean ± standard deviation (SD) change versus W0 or W2 using Kolmogorov–Smirnov, Wilcoxon’s signed rank or paired Student’s t test, * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001
SD standard deviation
$Intergroup comparison using an analysis of covariance (ANCOVA)