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. 2004 May 15;113(10):1390–1397. doi: 10.1172/JCI20402

Figure 5.

Figure 5

LPS-induced FP effacement and proteinuria are B7-1 dependent. (A) LPS injection (left panel) and PBS injection (right panel) do not cause renal inflammation 24 hours after injection in WT mice. (B) LPS injection induces B7-1 in podocytes as shown by double labeling with synaptopodin. (C) PBS-injected control mice do not upregulate B7-1. (D) LPS injection causes severe FP effacement within 24 hours in WT mice (left panel; arrows) but not in PBS-injected injected control animals (right panel). (E and F) B7-1 is upregulated in podocytes of LPS-treated SCID mice (E), but not in PBS-injected SCID controls (F). (G) LPS injection causes severe proteinuria in 129, C57BL/6, and BALB/c WT mice and SCID mice but not in B7-1_/_ mice. Asterisks indicate statistically significant changes (see text for details).