Fig. 3.

Kidney tissue histology in mice treated with vehicle control or dapagliflozin 40 mg/kg per day for >20 months and kidney pathology in rats treated with control or dapagliflozin 10 mg/kg per day for 90 weeks. a Kidney in dapagliflozin-treated (left) male mice and control (right). In both cases, the kidney cortex appears similar and shows normal glomeruli and renal cortical tubules. b Chronic progressive nephropathy (CPN) in control (left, moderate) and dapagliflozin-treated (right, severe) rats. The CPN is characterized by multifocal dilated tubules often filled with proteinaceous fluid, tubules with cytoplasmic basophilia and focally thickened tubular basement membranes, and foci of increased mononuclear cell infiltrates in the interstitium. There was exacerbation of CPN (increased severity) in the dapagliflozin-treated male rats (i.e., higher incidence of severe CPN in the dapagliflozin-treated males vs. controls). ×100 magnification