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. 2004 May 15;113(10):1456–1464. doi: 10.1172/JCI20864

Figure 6.

Figure 6

Morris water-maze. (A) Acquisition of place learning in the Morris water-maze hidden-platform task. Learning deficit in APP[V717I] transgenic mice was ameliorated in double-transgenic ADAM10-mo ∞ APP[V717I] mice. Lines represent mean ± SEM for 9_10 mice per group. *P < 0.05, **P < 0.01, APP[V717I] vs. control; _P < 0.05 APP[V717I] vs. ADAM10-mo ∞ APP[V717I] by Student's t test. (B) Memory test in Morris water-maze probe trial without platform. The deficit in APP[V717I] transgenic mice was improved in double-transgenic ADAM10-mo ∞ APP[V717I] mice. Bars represent mean ± SEM for 9_10 mice per group. *P < 0.05, APP[V717I] vs. control; _P < 0.05, APP[V717I] vs. ADAM10-mo ∞ APP[V717I] by Student's t test.