Table 3.
(A) Treatment-emergent non-hematologic adverse events occurring in greater than 10% of patients and (B) Grade 3–4 hematologic abnormalities (N = 46)
|
(A) | |||||
|---|---|---|---|---|---|
| |
Severity grade, n (%) |
||||
| Preferred term | 1 | 2 | 3 | 4 | Overall (N = 46) |
| Fatigue |
9 (20) |
8 (17) |
2 (4) |
0 |
19 (41) |
| Headache |
14 (30) |
2 (4) |
0 |
0 |
16 (35) |
| Chills |
11 (24) |
3 (7) |
1 (2) |
0 |
15 (33) |
| Pyrexia |
8 (17) |
4 (9) |
0 |
0 |
12 (26) |
| Nausea |
8 (17) |
2 (4) |
1 (2) |
0 |
11 (24) |
| Diarrhoea |
8 (17) |
1 (2) |
0 |
0 |
9 (20) |
| Dyspnoea |
4 (9) |
5 (11) |
0 |
0 |
9 (20) |
| Cough |
7 (15) |
0 |
0 |
0 |
7 (15) |
| Back pain |
3 (7) |
2 (4) |
1 (2) |
0 |
6 (13) |
| Depression |
4 (9) |
2 (4) |
0 |
0 |
6 (13) |
| Musculoskeletal pain |
4 (9) |
2 (4) |
0 |
0 |
6 (13) |
| Abdominal pain |
1 (2) |
2 (4) |
2 (4) |
0 |
5 (11) |
| Asthenia |
2 (4) |
2 (4) |
1 (2) |
0 |
5 (11) |
| Constipation |
5 (11) |
0 |
0 |
0 |
5 (11) |
| Oedema peripheral |
4 (9) |
1 (2) |
0 |
0 |
5 (11) |
| Oropharyngeal pain |
5 (11) |
0 |
0 |
0 |
5 (11) |
| Vomiting |
2 (4) |
2 (4) |
1 (2) |
0 |
5 (11) |
|
(B) | |||||
| |
Grade 3 |
Grade 4 |
|||
| |
n (%) |
n (%) |
|||
| Lymphopenia |
14 (30) |
5 (11) |
|||
| Neutropenia |
5 (11) |
1 (2) |
|||
| Thrombocytopenia |
7 (15) |
2 (4) |
|||
| Leukopenia | 6 (13) | 1 (2) | |||