. 2014 Feb 19;121(7):707–715. doi: 10.1007/s00702-014-1173-7

Table 3.

Influence of WIN 55,212-2 mesylate on the anticonvulsant action of the studied antiepileptic drugs in various animal seizure models

	Seizure model
Antiepileptic drug	MES	PTZ	6 Hz
Clobazam	↑ (2.5 and 5 mg/kg)^a	N.T.	0 (5 mg/kg)^d
Clonazepam	N.T.	0 (15 mg/kg)^c	↑ (2.5 and 5 mg/kg)^d
Phenobarbital	↑ (10 mg/kg)^b	↑ (15 mg/kg)^c	↑ (5 mg/kg)^d
Valproate	↑ (10 mg/kg)^b	↑ (15 mg/kg)^c	↑ (5 mg/kg)^d

Doses of WIN, which significantly potentiated the anticonvulsant activity of the studied antiepileptic drugs, are given in parentheses

MES—maximal electroshock-induced seizure test, PTZ—pentylenetetrazole-induced seizure test, 6 Hz—psychomotor (limbic) 6 Hz-induced seizure test, ↑—increase in the anticonvulsant activity of the studied antiepileptic drug, 0—no significant effect despite the administration of WIN at a maximally tested dose, N.T.—not tested

^aunpublished data

^bResults from Luszczki et al. 2011b

^cResults from Luszczki et al. 2011a

^dResults from this study