Table 2.

Valve-related baseline characteristics

	Conventional AVR		TAVI		P-value of global hypothesis	P-values of pairwise comparisons [alpha level has to be corrected by the Bonferoni–Holm–Shaffer method for multiple comparisons (6-3-3-3-2-1-rule)]
	Without CABG	With CABG	Transvascular	Transapical	H0: no differences between any procedures	H0: AVR = AVR + CABG	H0: AVR = TV TAVI	H0: AVR = TA TAVI	H0: AVR + CABG = TV TAVI	H0: AVR + CABG = TA TAVI	H0: TV TAVI = TA TAVI
Aortic valve orifice (echo; cm2)	0.86 ± 0.66	0.85 ± 0.50	0.68 ± 0.25	0.68 ± 0.20	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	0.416
Delta Pmean (mmHg)	44.2 ± 19.5	41.1 ± 17.6	46.1 ± 17.6	43.7 ± 16.3	<0.001	<0.001	0.118	0.014	<0.001	0.002	<0.001
Delta Pmax (mmHg)	70.1 ± 29.8	65.7 ± 26.7	73.4 ± 26.7	71.4 ± 25.0	<0.001	<0.001	0.012	0.760	<0.001	<0.001	0.052
Degree of calcification (%)
Low	7.5	7.1	5.6	3.7	<0.001	0.535	0.002	<0.001	0.025	<0.001	0.018
Average	24.1	24.9	28.8	23.5	<0.001	0.422	<0.001	0.668	0.001	0.366	0.001
Heavy	57.3	62.0	63.9	65.9	<0.001	<0.001	<0.001	<0.001	0.149	0.023	0.263
Concomitant mitral regurgitation (%)
None	40.0	35.9	11.6	17.4	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001
Grade I	44.7	48.2	57.8	54.4	<0.001	0.001	<0.001	<0.001	<0.001	<0.001	0.055
Grade II	10.9	12.9	26.6	26.0	<0.001	0.005	<0.001	<0.001	<0.001	<0.001	0.719
Grade III	3.7	2.7	3.9	2.0	0.001	0.009	0.715	0.003	0.012	0.193	0.002
Grade IV	0.7	0.3	0.1	0.2	<0.001	0.011	<0.001	0.056	0.126	0.739	0.590