Table 4.
Correlations Between Proteins Concentrations in CSF and Plasma
| CSF Correlations | Plasma Correlations | ||||||||
|---|---|---|---|---|---|---|---|---|---|
|
|
|
||||||||
| Target 1 | Target 2 | Healthy | AD | Effect due to AD | Target 1 | Target 2 | Healthy | AD | Effect due to AD |
| Target 1 | Target 2 | Healthy | AD | Effect due to AD | Target 1 | Target 2 | Healthy | AD | Effect due to AD |
| Aβ40 | Aβ42 | 0.0368* | 0.5364 | Disrupted correlation | Aβ40 | Aβ42 | 0.0167* | 0.9768 | Disrupted correlation |
| Aβ40 | ApoE | 0.4279 | 0.0154* | Correlation | Aβ40 | Clusterin | 0.0333* | 0.7033 | Disrupted correlation |
| Aβ40 | SPARCL1 | 0.0279* | 0.7033 | Disrupted correlation | Aβ40 | Fibrinogen | 0.3556 | 0.0368* | Correlation |
| Aβ40 | Tau | 0.1710 | 0.0458* | Correlation | Aβ40 | IL-12 | 0.0167* | 0.0962 | Disrupted correlation |
| Aβ40 | Tetranectin | 0.0831 | 0.0072** | Correlation | Aβ40 | Tau | 0.0333* | 0.2675 | Disrupted correlation |
| Aβ42 | MCP-1 | 0.4976 | 0.0072** | Correlation | Aβ42 | Clusterin | 0.0072** | 0.0458* | Weaker correlation |
| ApoE | MCP-1 | 0.0067** | 0.0831 | Disrupted correlation | Aβ42 | Tau | 0.0154* | 0.1323 | Disrupted correlation |
| ApoE | Tau | 0.0368* | 0.0458* | No change in correlation | ApoE | Fibrinogen | 0.7033 | 0.0368* | Correlation |
| ApoE | Tetranectin | 0.0458* | 0.0368* | No change in correlation | ApoE | IL-12 | 0.0154* | 0.7930 | Disrupted correlation |
| Clusterin | FGF-basic | 0.5560 | 0.0107* | Correlation | ApoE | Tau | 0.1710 | 0.0046** | Correlation |
| Clusterin | MCP-1 | 0.0341* | 0.9349 | Disrupted correlation | ApoE | Tetranectin | 0.4618 | 0.0368* | Correlation |
| FGF-basic | MIP-1beta | 0.0480* | 0.3268 | Disrupted correlation | Clusterin | Tau | 0.0046** | 0.2162 | Disrupted correlation |
| MCP-1 | Tau | 0.0123* | 0.3599 | Disrupted correlation | Fibrinogen | Tau | 0.9768 | 0.0154* | Correlation |
| MCP-1 | Tetranectin | 0.0480* | 0.2992 | Disrupted correlation | Fibrinogen | Tetranectin | 0.0831 | 0.0107* | Correlation |
| Tau | Tetranectin | 0.0022** | 0.0107* | Weaker correlation | IL-12 | Tau | 0.0107* | 0.7520 | Disrupted correlation |
| MCP-1 | Tetranectin | 0.0458* | 0.3268 | Disrupted correlation | |||||
| Tau | Tetranectin | 0.5364 | 0.0072** | Correlation | |||||
Spearman correlation coefficients were determined for all protein pairings in CSF and plasma. A p-value 0.05 was considered statistically significant. Target markers showing significant correlations either in the healthy or disease state are shown.
*
p ≤ 0.05;
**
p ≤ 0.01.