Table 5.
The Power of Individual Proteins Within the Biomarkers Panels
| Marker | Healthy CSF | AD CSF | Healthy Plasma | AD Plasma | ||||
|---|---|---|---|---|---|---|---|---|
|
| ||||||||
| Rank | Power (%) | Rank | Power (%) | Rank | Power (%) | Rank | Power (%) | |
| Aβ40 | 4 | 40.58 | 21 | 0 | 14 | 5.13 | 12 | 0.002 |
| Aβ42 | 5 | 29.68 | 17 | 0 | 3 | 56.67 | 10 | 0.07 |
| ApoE | 11 | 10.48 | 6 | 4.50 | 20 | 0.002 | 4 | 4.52 |
| Clusterin | 17 | 0.57 | 8 | 2.71 | 18 | 0.03 | 8 | 1.97 |
| EGF | 21 | 0.02 | 9 | 0.82 | 22 | 0.0003 | 5 | 3.21 |
| Eotaxin | 14 | 4.00 | 14 | 0.0006 | 7 | 19.08 | 18 | 0 |
| FGF-basic | 6 | 26.37 | 19 | 0 | 1 | 82.13 | 15 | 0 |
| Fibrinogen | 7 | 18.41 | 18 | 0 | 21 | 0.002 | 7 | 2.41 |
| G-CSF | 2 | 52.30 | 22 | 0 | 23 | 0.0001 | 3 | 5.02 |
| HGF | 22 | 0.013 | 10 | 0.62 | 5 | 35.51 | 19 | 0 |
| IFN-α | 16 | 2.45 | 13 | 0.002 | 13 | 6.19 | 20 | 0 |
| IL-12 | 19 | 0.46 | 12 | 0.06 | 12 | 7.33 | 23 | 0 |
| IL-1RA | 1 | 66.43 | 20 | 0 | 2 | 73.54 | 16 | 0 |
| IL-2R | 23 | 0.0003 | 7 | 3.54 | 10 | 12.74 | 21 | 0 |
| IL-6 | 8 | 13.92 | 23 | 0 | - | - | - | - |
| IL-8 | 13 | 4.34 | 15 | 0.0002 | 4 | 44.19 | 22 | 0 |
| IP-10 | 20 | 0.10 | 11 | 0.21 | 17 | 1.37 | 11 | 0.003 |
| Keratin 9 | 24 | 0 | 1 | 98.76 | 24 | 0 | 2 | 7.96 |
| MCP-1 | 24 | 0 | 4 | 8.57 | 9 | 15.56 | 17 | 0 |
| MIG | 9 | 13.14 | 24 | 0 | 16 | 3.06 | 13 | 0.0003 |
| MIP-1α | 3 | 46.84 | 24 | 0 | 6 | 23.96 | 24 | 0 |
| MIP-1β | 24 | 0 | 5 | 6.23 | 24 | 0 | 1 | 28.05 |
| SPARCL1 | 12 | 6.66 | 16 | 0 | 11 | 7.68 | 14 | 0 |
| Tau | 15 | 3.92 | 2 | 15.68 | 19 | 0.02 | 6 | 2.48 |
| Tetranectin | 18 | 0.56 | 3 | 14.95 | 15 | 3.86 | 9 | 1.49 |
| VEGF | 10 | 11.85 | 24 | 0 | 8 | 17.48 | 24 | 0 |
Contribution of each individual marker to the overall power of the biomarker panels. Values are presented as the percentage of a cohort that can be accurately identified using that marker. Each marker is ranked according to its contribution to the strength of the biomarker panel.