Table 4.
Association of -238G>A polymorphism (genotypes) of the TNF-α gene with clinical variables of cystic fibrosis patients
| Clinical variables | Groups | Genotypic distribution | |||
|---|---|---|---|---|---|
|
| |||||
| G/G | OR (95%CI) | G/A | OR (95%CI) | ||
| Age at diagnosis | <12 months | 4 | 0.44 (0.09-1.89) | 23 | 2.26 (0.53-10.49) |
| 13 to 36 months | 4 | 5.39 (0.98-30.7) | 4 | 0.19 (0.03-1.02) | |
| >36 months | 2 | 0.62 (0.08-3.22) | 11 | 1.61 (0.31-12.67) | |
| Onset of pulmonary symptoms | <12 months | 6 | 0.53 (0.12-2.56) | 26 | 1.90 (0.39-8.64) |
| 13 to 36 months | 2 | 1.49 (0.17-9.18) | 5 | 0.67 (0.11-5.81) | |
| >36 months | 2 | 1.91 (0.21-12.84) | 4 | 0.52 (0.08-4.72) | |
| No clinical symptom | 0 | - | 2 | - | |
| Onset of digestive symptoms | <12 months | 7 | 0.88 (0.15-7.54) | 24 | 1.14 (0.13-6.89) |
| 13 to 36 months | 2 | 3.82 (0.35-42.28) | 2 | 0.26 (0.02-2.88) | |
| >36 months | 0 | - | 4 | - | |
| No clinical symptom | 0 | - | 1 | - | |
| Age for the first infection by Pseudomonas aeruginosa | <12 months | 4 | 1.93 (0.39-9.10) | 11 | 0.52 (0.11-2.54) |
| 13 to 36 months | 3 | 1.22 (0.22-5.87) | 11 | 0.82 (0.17-4.63) | |
| >36 months | 2 | 0.71 (0.09-3.79) | 11 | 1.42 (0.26-11.3) | |
| No clinical symptom | 0 | - | 5 | - | |
| Forced expiratory volume in first second of the FVC | Normal (>80%) | 3 | 1 (0.14-6.90) | 12 | 1 (0.14-6.90) |
| Mild (60-80%) | 1 | 0.61 (0.02-5.66) | 6 | 1.64 (0.18-45.91) | |
| Moderate (40-60%) | 1 | 2.13 (0.06-33.11) | 2 | 0.47 (0.03-15.98) | |
| Severe (<40%) | 1 | 1 (0.03-10.34) | 4 | 1 (0.10-29.45) | |
| Shwachman-Kulczycki score | Excellent (86-100) | 4 | 2.35 (0.37-16.63) | 3 | 1.36 (0.19-8.90) |
| Good (71-85) | 1 | 0.16 (0.006-1.39) | 6 | 6.26 (0.72-172.2) | |
| Mild (56-70) | 0 | - | 1 | - | |
| Moderate (41-55) | 4 | 1.63 (0.27-10.02) | 4 | 0.61 (0.10-3.69) | |
| Severe (≤40) | 1 | - | 0 | - | |
| Kanga score | Exacerbated | 2 | 2.86 (0.29-22.87) | 3 | 0.35 (0.04-3.41) |
| Non exacerbated | 7 | 0.35 (0.04-3.41) | 31 | 2.86 | |
| Transcutaneous oxygen saturation of hemoglobin | Normal (>95%) | 9 | 4.38 (0.60-107.9) | 22 | 0.23 (0.009-1.66) |
| Mild (91-95%) | 1 | 0.30 (0.01-2.26) | 9 | 3.30 (0.44-82.39) | |
| Moderate (85-90%) | 0 | - | 1 | - | |
| Severe (<85%) | 0 | - | 1 | - | |
TNF-α = tumor necrosis factor; FVC = forced ventilator capacity. Statistical analysis performed by χ2 test and Fisher’s exact test.