Table 5.
Association of -238G>A polymorphism (alleles) of the TNF-α gene with clinical variables of cystic fibrosis patients
| Clinical variables | Groups | Allelic distribution | |||
|---|---|---|---|---|---|
|
| |||||
| G allele | OR (95%CI) | A allele | OR (95%CI) | ||
| Age at diagnosis | <12 months | 50 | 2.07 (0.53-8.86) | 4 | 0.48 (0.11-1.89) |
| 13 to 36 months | 12 | 0.25 (0.06-1.13) | 4 | 4.03 (0.89-17.01) | |
| >36 months | 24 | 1.54 (0.33-11.29) | 2 | 0.65 (0.09-3.05) | |
| Onset of pulmonary symptoms | <12 months | 58 | 17.46 (0.40-6.99) | 6 | 0.57 (0.14-2.50) |
| 13 to 36 months | 12 | 0.71 (0.14-5.40) | 2 | 1.41 (0.19-7.05) | |
| >36 months | 10 | 0.58 (0.11-4.46) | 2 | 1.74 (0.22-8.91) | |
| No clinical symptom | 4 | - | 0 | - | |
| Onset of digestive symptoms | <12 months | 55 | 1.12 (0.15-5.71) | 7 | 0.89 (0.18-6.86) |
| 13 to 36 months | 6 | 0.34 (0.06-2.85) | 2 | 2.94 (0.35-17.31) | |
| >36 months | 8 | - | 0 | - | |
| No clinical symptom | 2 | - | 0 | - | |
| Age for the first infection by Pseudomonas aeruginosa | <12 months | 26 | 0.67 (0.16-3.01) | 4 | 1.5 (0.33-6.42) |
| 13 to 36 months | 25 | 1 (0.23-5.25) | 3 | 1 (0.19-4.37) | |
| >36 months | 24 | 1.64 (0.34-12.25) | 2 | 0.61(0.08-2.98) | |
| No clinical symptom | 10 | - | 0 | - | |
| Forced expiratory volume in first second of the FVC | Normal (>80%) | 27 | 1 (0.16-6.29) | 3 | 1 (0.16-6.29) |
| Mild (60-80%) | 13 | 1.57 (0.19-40.47) | 1 | 0.64 (0.02-5.13) | |
| Moderate (40-60%) | 5 | 0.52 (0.06-14.46) | 1 | 1.93 (0.07-18.17) | |
| Severe (<40%) | 9 | 1 (0.12-26.31) | 1 | 1 (0.04-8.40) | |
| Shwachman-Kulczycki score | Excellent (86-100) | 10 | 0.54 (0.12-2.59) | 4 | 1.84 (0.39-8.22) |
| Good (71-85) | 13 | 4.56 (0.64-110.9) | 1 | 0.22 (0.009-1.56) | |
| Mild (56-70) | 2 | - | 0 | - | |
| Moderate (41-55) | 12 | 0.70 (0.16-3.28) | 4 | 1.43 (0.31-6.26) | |
| Severe (≤40) | 1 | 0.25 (0.006-10.51) | 1 | 3.95 (0.10-164.2) | |
| Kanga score | Exacerbated | 8 | 0.41 (0.07-3.32) | 2 | 2.43 (0.30-13.36) |
| Non exacerbated | 69 | 2.43 (0.30-13.36) | 7 | 0.41 (0.07-3.32) | |
| Transcutaneous oxygen saturation of hemoglobin | Normal (>95%) | 53 | 0.26 (0.01-1.71) | 9 | 3.86 (0.58-89.85) |
| Mild (91-95%) | 19 | 2.97 (0.44-69.6) | 1 | 0.34 (0.01-2.25) | |
| Moderate (85-90%) | 2 | - | 0 | - | |
| Severe (<85%) | 2 | - | 0 | - | |
TNF-α = tumor necrosis factor; FVC = forced ventilator capacity. Statistical analysis performed by χ2 test and Fisher’s exact test.