Table 6.
Association of the -238G>A e -308G>A polymorphisms of the TNF-α gene with clinical variables with numerical distribution
| Clinical variable | -238G>A genotype | N (%) | Mean | Standard deviation | p-value |
| Age at diagnosis (months) | GG | 34 (77.27) | 30.23 | 40.11 | 1.0 |
| GA | 10 (22.72) | 27.09 | 39.39 | ||
| Onset of pulmonary symptoms (months) | GG | 32 (78.04) | 22.22 | 44.31 | 1.0 |
| GA | 9 (21.95) | 13 | 18.43 | ||
| Onset of digestive symptoms (months) | GG | 20 (74.04) | 22.45 | 29.39 | 0.126 |
| GA | 17 (62.96) | 5 | 3.31 | ||
| Forced expiratory volume in first second of the FVC | AG | 6 (19.35) | 75 | 33.97 | 0.4973 |
| GG | 25 (80.64) | 73 | 28.39 | ||
| Shwachman-Kulczycki score | AG | 4 | 85 | 12.90 | 1.0 |
| GG | 20 | 74 | 13.38 | ||
| Clinical variable | -308G>A genotype | N (%) | Mean | Standard deviation | p-value |
| Age at diagnosis (months) | GG | 7 (15.90) | 12.71 | 13.04 | GG vs GA = 1.0 |
| GA | 8 (18.18) | 39.75 | 66.42 | GG vs AA = 1.0 | |
| AA | 29 (65.90) | 31.03 | 33.97 | GA vs AA = 0.031 | |
| Onset of pulmonary symptoms (months) | GG | 7 (17.07) | 9.28 | 15.14 | GG vs GA = 1.0 |
| GA | 8 (19.51) | 31.85 | 62.68 | GG vs AA = 1.0 | |
| AA | 26 (63.41) | 18.30 | 36.96 | GA vs AA = 0.226 | |
| Onset of digestive symptoms (months) | GG | 3 (11.11) | 4.33 | 1.52 | GG vs GA = 1.0 |
| GA | 4 (14.81) | 23.25 | 25.07 | GG vs AA = 1.0 | |
| AA | 20 (74.07) | 18.9 | 28.54 | GA vs AA = 1.0 | |
| Forced expiratory volume in first second of the FVC | GG | 3 (9.68) | 85 | 13.45 | GG vs GA = 1.0 |
| GA | 4 (12.90) | 82 | 48.39 | GG vs AA = 1.0 | |
| AA | 24 (77.42) | 71 | 27.10 | GG vs GA = 0.253 | |
| Shwachman-Kulczycki score | GG | 4 (16.16) | 74 | 11.81 | GG vs GA = 1.0 |
| GA | 4 (16.16) | 62 | 14.14 | GG vs AA = 1.0 | |
| AA | 16 (66.66) | 81 | 15.62 | GA vs GG = 1.0 |
TNF-α = tumor necrosis factor; FVC = forced ventilator capacity; N = number of patients. Positive p-value is in bold. Statistical analysis performed by Kruskal-Wallis test and T-student test.