Table 7.
Association of -308G>A polymorphism (genotypes) of the TNF-α gene with clinical variables of cystic fibrosis patients
| Clinical variable | Groups | Genotype distribution | |||||
|---|---|---|---|---|---|---|---|
|
| |||||||
| G/G | OR (95%CI) | G/A | OR (95%CI) | A/A | OR (95%CI) | ||
| Age at diagnosis | <12 months | 5 | 2.13 (0.37-17.39) | 3 | 0.32 (0.06-1.49) | 19 | 1.45 (0.42-5.03) |
| 13 to 36 months | 1 | 0.81 (0.03-6.80) | 3 | 3.29 (0.53-18.61) | 4 | 0.44 (0.08-2.23) | |
| >36 months | 1 | 0.41 (0.02-3.18) | 3 | 1.44 (0.25-6.98) | 9 | 1.17 (0.30-5.18) | |
| Onset of pulmonary symptoms | <12 months | 4 | 0.41 (0.07-2.55) | 8 | 3.31 (0.45-82.17) | 22 | 2.92 (0.53-17.87) |
| 13 to 36 months | 3 | 6.00 (0.85-41.44) | 1 | 0.63 (0.024-5.17) | 3 | 0.36 (0.06-1.97) | |
| >36 months | 0 | - | 0 | - | 5 | - | |
| No clinical symptom | 0 | - | 0 | - | 1 | - | |
| Onset of digestive symptoms | <12 months | 3 | 0.33 (0.04-3.32) | 7 | - | 21 | 5.98 (1.06-49.68) |
| 13 to 36 months | 1 | 2.50 (0.08-30.47) | 0 | - | 3 | 1.36 (0.13-39.32) | |
| >36 months | 1 | 2.50 (0.08-30.47) | 0 | - | 3 | 1.36 (0.13-39.32) | |
| Age for the first infection by Pseudomonas aeruginosa | <12 months | 7 | - | 7 | 10.2 (1.86-84.09) | 1 | 0.08 (0.0003-0.07) |
| 13 to 36 months | 0 | - | 2 | 1 | 11 | 1 | |
| >36 months | 0 | - | 0 | - | 14 | - | |
| No clinical symptom | 0 | - | 0 | - | 5 | - | |
| Forced expiratory volume in first second of the FVC | Normal (>80%) | 2 | 2.25 (0.16-72.3) | 2 | 1.07 (0.10-11.6) | 11 | 0.54 (0.10-3.78) |
| Mild (60-80%) | 1 | 1.48 (0.04-22.1) | 1 | 0.95 (0.32-10.58) | 6 | 0.84 (0.13-7.65) | |
| Moderate (40-60%) | 0 | - | 0 | - | 3 | - | |
| Severe (<40%) | 0 | - | 1 | 1.87 (0.06-22.97) | 4 | 1.19 (0.12-34.39) | |
| Shwachman-Kulczycki score | Excellent (86-100) | 2 | 1.82 (0.17-15.96) | 2 | 0.74 (0.08-5.15) | 3 | 0.68 (0.10-4.29) |
| Good (71-85) | 2 | 1.82 (0.17-15.96) | 1 | 0.32 (0.01-2.91) | 4 | 1.48 (0.23-10.16) | |
| Mild (56-70) | 1 | - | 0 | - | 0 | - | |
| Moderate (41-55) | 0 | - | 4 | 4.04 (0.60-31.01) | 4 | 1 (0.17-5.97) | |
| Severe (≤40) | 0 | - | 0 | - | 1 | - | |
| Kanga score | Exacerbated | 0 | - | 2 | 4.19 (0.41-35.52) | 3 | 0.62 (0.08-5.81) |
| Non exacerbated | 6 | - | 5 | 0.24 (0.028-2.42) | 27 | 1.62 (0.17-12.31) | |
| Transcutaneous oxygen saturation of hemoglobin | Normal (>95%) | 6 | - | 6 | 2.59 (0.33-66.37) | 19 | 0.15 (0.0006-1.05) |
| Mild (91-95%) | 0 | - | 1 | 0.51 (0.02-4.10) | 9 | 4.99 (0.69-122.5) | |
| Moderate (85-90%) | 0 | - | 0 | - | 1 | - | |
| Severe (<85%) | 0 | - | 0 | - | 1 | - | |
TNF-α = tumor necrosis factor; FVC = forced ventilator capacity. Positive p-value is in bold. Statistical analysis performed by χ2 test and Fisher’s exact test.