Table 8.
Association of -308G>A polymorphism (alleles) of the TNF-α gene with clinical variables of cystic fibrosis patients
| Clinical variables | Groups | Allelic distribution | |||
|---|---|---|---|---|---|
|
| |||||
| G allele | OR (95%CI) | A Allele | OR (95%CI) | ||
| Age at diagnosis | <12 months | 13 | 1.01 (0.39-2.69) | 41 | 0.99 (0.37-2.56) |
| 13 to 36 months | 5 | 1.56 (0.44-5.06) | 11 | 0.64 (0.20-2.29) | |
| >36 months | 5 | 0.69 (0.21-2.05) | 21 | 1.45 (0.48-4.87) | |
| Onset of pulmonary symptoms | <12 months | 16 | 0.75 (0.26-2.25) | 52 | 1.33 (0.45-3.79) |
| 13 to 36 months | 7 | 3.81 (1.13-12.97) | 7 | 0.26 (0.08-0.89) | |
| >36 months | 0 | - | 10 | - | |
| No clinical symptom | 0 | - | 2 | - | |
| Onset of digestive symptoms | <12 months | 13 | 0.80 (0.22-3.29) | 49 | 1.25 (0.30-4.48) |
| 13 to 36 months | 2 | 1.22 (0.16-6.44) | 6 | 0.82 (0.16-6.43) | |
| >36 months | 2 | 1.22 (0.16-6.44) | 6 | 0.82 (0.16-6.43) | |
| Age for the first infection by Pseudomonas aeruginosa | <12 months | 21 | 66.77 (15.18-482.7) | 9 | 0.15 (0.002-0.07) |
| 13 to 36 months | 2 | 0.15 (0.02-0.62) | 24 | 6.69 (1.62-45.66) | |
| >36 months | 0 | - | 28 | - | |
| No clinical symptom | 0 | - | 10 | - | |
| Forced expiratory volume in first second of the FVC | Normal (>80%) | 6 | 2.30 (0.52-12.34) | 24 | 0.44 (0.08-1.94) |
| Mild (60-80%) | 3 | 1.49 (0.27-6.91) | 13 | 0.67 (0.14-3.70) | |
| Moderate (40-60%) | 0 | - | 6 | - | |
| Severe (<40%) | 0 | - | 9 | - | |
| Shwachman-Kulczycki score | Excellent (86-100) | 6 | 2.41 (0.60-9.84) | 8 | 0.41 (0.10-1.68) |
| Good (71-85) | 5 | 1.51 (0.36-6.08) | 9 | 0.66 (0.16-2.77) | |
| Mild (56-70) | 2 | - | 0 | - | |
| Moderate (41-55) | 0 | - | 12 | - | |
| Severe (≤40) | 0 | - | 2 | - | |
| Kanga score | Exacerbated | 2 | 0.87 (0.12-4.20) | 8 | 1.15 (0.24-8.58) |
| Non exacerbated | 17 | 1 | 59 | 1 | |
| Transcutaneous oxygen saturation of hemoglobin | Normal (>95%) | 18 | 9.24 (1.53-206.1) | 44 | 0.11 (0.005-0.66) |
| Mild (91-95%) | 1 | 0.14 (0.006-0.87) | 19 | 7.01 (1.14-157.4) | |
| Moderate (85-90%) | 0 | - | 2 | - | |
| Severe (<85%) | 0 | - | 2 | - | |
TNF-α = tumor necrosis factor; FVC = forced ventilator capacity. Positive p-value is in bold. Statistical analysis performed by χ2 test and Fisher’s exact test.