Table 2.

Simple and fully adjusted models examining association of IGF-I, IGF-II and IGF molar ratio with FEV₁, FVC & FEV₁/FVC ratio at Phase 2

Phase 2	FEV1				FVC				FEV1/FVC Ratio (%)
	Coeff	95% CI		P	Coeff	95% CI		P	Coeff	95% CI		P
IGF-I
Model 1*	0.035	-0.004	0.074	0.08	0.019	-0.024	0.062	0.39	0.6	0.0	1.2	0.05
Model 2**	0.011	-0.026	0.049	0.55	-0.001	-0.043	0.041	0.96	0.4	-0.2	1.0	0.18
Model 3***	0.021	-0.005	0.047	0.11	0.008	-0.025	0.040	0.65	0.5	-0.1	1.0	0.11
IGF-II
Model 1*	0.007	-0.035	0.050	0.74	0.013	-0.033	0.059	0.59	-0.1	-0.8	0.5	0.70
Model 2**	-0.002	-0.042	0.038	0.93	0.011	-0.033	0.056	0.62	-0.3	-1.0	0.3	0.32
Model 3***	0.006	-0.022	0.034	0.69	0.022	-0.013	0.057	0.23	-0.3	-0.9	0.3	0.38
IGFBP3
Model 1*	-0.002	-0.043	0.039	0.91	0.007	-0.038	0.051	0.77	-0.2	-0.8	0.4	0.54
Model 2**	-0.003	-0.042	0.035	0.86	0.011	-0.032	0.054	0.61	-0.3	-0.9	0.3	0.28
Model 3***	0.015	-0.012	0.042	0.29	0.031	-0.002	0.065	0.07	-0.2	-0.8	0.4	0.47
Molar ratio
Model 1*	0.026	-0.014	0.066	0.21	0.000	-0.044	0.044	1.00	0.7	0.1	1.3	0.02
Model 2**	0.004	-0.034	0.042	0.85	-0.022	-0.065	0.021	0.31	0.6	0.0	1.2	0.05
Model 3***	0.007	-0.020	0.034	0.61	-0.021	-0.054	0.012	0.22	0.6	0.1	1.2	0.03

^*Model 1 = adjusted for age, height and IGF laboratory batch.

^**Model 2 = Model 1 + adjusted for BMI, smoking and social class.

^***Model 3 = Model 2 + adjusted for predicted FEV₁ or FVC <80%.