Table 3.

Simple and fully adjusted models examining association of IGF-I, IGF-II and IGF molar ratio with FEV₁, FVC & FEV₁/FVC ratio at Phase 2 and 5, respectively

Phase 5	FEV1				FVC				FEV1/FVC Ratio (%)
	Coeff	95% CI		P	Coeff	95% CI		P	Coeff	95% CI		P
IGF-I
Model 1*	0.030	-0.011	0.072	0.15	0.022	-0.025	0.070	0.36	0.4	-0.4	1.2	0.33
Model 2**	0.015	-0.024	0.055	0.45	0.008	-0.039	0.054	0.75	0.3	-0.5	1.0	0.50
Model 3***	0.023	-0.011	0.058	0.18	0.014	-0.029	0.056	0.53	0.4	-0.3	1.1	0.27
IGF-II
Model 1*	0.012	-0.031	0.056	0.58	0.015	-0.035	0.065	0.56	0.1	-0.7	1.0	0.74
Model 2**	0.007	-0.035	0.048	0.75	0.015	-0.034	0.064	0.54	0.0	-0.8	0.7	0.90
Model 3***	0.017	-0.020	0.054	0.36	0.032	-0.014	0.078	0.17	0.0	-0.8	0.8	0.95
IGFBP-3
Model 1*	0.021	-0.024	0.066	0.37	-0.010	-0.062	0.041	0.70	0.9	0.0	1.8	0.04
Model 2**	0.013	-0.030	0.055	0.57	-0.007	-0.058	0.043	0.77	0.6	-0.3	1.4	0.19
Model 3***	0.026	-0.012	0.063	0.18	0.008	-0.038	0.054	0.74	0.7	-0.1	1.5	0.09
Molar ratio
Model 1*	0.016	-0.027	0.060	0.45	0.028	-0.022	0.077	0.27	-0.2	-1.0	0.6	0.64
Model 2**	0.007	-0.034	0.049	0.73	0.012	-0.037	0.061	0.64	-0.1	-0.9	0.7	0.81
Model 3***	0.011	-0.025	0.047	0.56	0.010	-0.034	0.055	0.65	0.0	-0.7	0.8	0.96

^*Model 1 = adjusted for age, height and IGF laboratory batch.

^**Model 2 = Model 1 + adjusted for BMI, smoking and social class.

^***Model 3 = Model 2 + adjusted for predicted FEV₁ or FVC <80%.