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. 2014 Jun 13;14:77. doi: 10.1186/1471-2261-14-77

Table 1.

Model input parameters

Parameter Deterministic values (min – max range) Distribution Source
Costs & event occurrence
  
  
  
Cost of conventional cTnT test
 €17.11(12.8-21.4)
 Beta PERT
 Commercial price at MUMC
Cost of new hsTnT test
 €31.5 (23.6-39.4)
 Beta PERT
 Time & motion study*
Cost of AMI in 1st year
 € 12446 ( 9334–15557)
 GAMMA
 [21]
Cost of AMI in subsequent year
 € 2092 (1569–2615)
 GAMMA
 [21]
Utility score for AMI
 0.725 (0.544-0.906)
 BETA
 [19]
Discount rate: cost
 0.4
 Fixed
 [23]
Discount rate: Effect
 0.15
 Fixed
 [23]
Prevalence of AMI among patients presenting with chest pain
 0.30 (0.23 -0.38)
 Beta PERT
 [5]
Risk adjusted mortality ratio among inappropriately discharged AMI patients
 1.9 (1.43 -2.38)
 Beta PERT
 [20]
Life expectancy of AMI survivor (years)
 8.3 (6.23-10.38)
 Beta PERT
 [16]
Diagnostic accuracy
  
  
 [17]
cTnT sensitivity at ≤6 hours
 0.44 (0.32-0.56)
 BETA
cTnT sensitivity at ≤12 hours
 0.93 (0.85-0.97)
 BETA
cTnT specificity at ≤6 hours
 0.92 (0.88-0.95)
 BETA
cTnT specificity at ≤12 hours
 0.85 (0.76-0.91)
 BETA
hsTnT sensitivity at ≤6 hours
 0.94 (0.87-0.98)
 BETA
hsTnT sensitivity at ≤12 hours
 0.95 (0.91-0.98)
 BETA
hsTnT specificity at ≤6 hours
 0.52 (0.39-0.65)
 BETA
hsTnT specificity at ≤12 hours
 0.51 (0.40-0.62)
 BETA
hsTnT + hFABP sensitivity at ≤6 hours
 0.97 (0.90-0.99)
 BETA
hsTnT + hFABP sensitivity at ≤12 hours
 0.97 (0.93-0.99)
 BETA
hsTnT + hFABP specificity at ≤ 6 hours
 0.39 (0.27-0.51)
 BETA
hsTnT + hFABP specificity at ≤ 12 hours
 0.38 (0.27-0.49)
 BETA
Event occurrence
  
  
Average of AMI mortality among patients given PPCI within 4 hours of presentation
 0.062 (0.0468-0.0780)
 Beta PERT
 Calculated from [3]
AMI mortality among patients given PPCI after 4 hours of presentation
 0.103 (0.077-0.1288)
 Beta PERT
 [3]
PPCI procedure related mortality 0.0072 (0.0054-0.009) Beta PERT [18]

*Time & Motion study done at Pathology Laboratory, MUMC.