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. 2014 Jun 15;9:14. doi: 10.1186/1749-8104-9-14

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Copyright © 2014 Sellers et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Dlx2 induces GABAergic differentiation and suppresses rostral thalamic (rTh) subtype identity. Key rTh transcription factor genes Gata2 and Gata3 are expressed in the pTh of Dlx1/2 compound knockout mice (red arrows), providing strong evidence that Dlx1/2 are required to maintain pTh identity (A). Ectopic expression of the pTh gene Dlx2 in the glutamatergic cTh, induces GABAergic differentiation, visualized by induction of the panGABAergic markers Gad1 and proneural gene Ascl1(B). Ectopic expression of Dlx2 induces pTh GABA subtype progenitor markers in the rTh and cTh (Arx, Meis2) (C). Consistent with a role in controlling GABA subtype identity in the thalamus, rTh markers (Tal1, Sox14) are downregulated upon ectopic expression of Dlx2(D). A schematic summary of the effect of ectopic Dlx2 expression in the progenitor domains rTh and cTh (E). Scale bars: 100 μm.