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. 2014 Jul;77(1):20–26. doi: 10.1016/j.jpsychores.2014.04.002

Table B.

Variation of non-serious adverse events and baseline variables by centre (N %)

A B C D E F P value
Median (quartiles) NSAE count 3 (1, 4) 3 (2, 5) 4 (2, 6) 7 (4, 10) 8 (4, 13) 10 (6, 15) < .001*
NSAE ≤ 4 (313) 86 (78) 74 (69) 78 (58%) 38 (34) 32 (29) 5 (8)
NSAE > 4 (327) 24 (22) 34 (31) 57 (42%) 75 (66) 79 (71) 58 (92) < .0001#
Chalder fatigue 28.5 (3.6)¶ 28.1 (3.4) 27.2 (4.1) 28.8 (3.6) 28.0 (3.9) 29.2 (3.5) .005$
SF36 PF 39 (16) 40 (16) 41 (13) 36 (16) 35 (16) 37 (16) .006
CFS symptoms 5.0 (1.7) 4.6 (1.7) 4.3 (1.8) 4.6 (1.8) 4.7 (1.8) 5.4 (1.8) .01
HADS anxiety 7.7 (4.4) 7.3 (3.7) 8.1 (4.6) 7.9 (4.2) 8.4 (4.2) 9.3 (3.8) .008
HADS depression 8.3 (3.5) 7.6 (3.2) 8.2 (3.8) 8.4 (4.0) 8.4 (4.0) 9.4 (4.2) .02
PHQ-15 14.4 (3.9) 13.8 (4.3) 12.9 (4.4) 14.2 (4.2) 14.8 (5.2) 15.7 (5.5) < .001
BMI 25.2 (4.7) 27.0 (5.5) 24.0 (5.5) 25.5 (4.7) 25.1 (5.0) 27.2 (5.3) .04

*Kruskal–Wallis. #χ2 (5 df) = 129.4, P < .0001. NSAE = non-serious adverse events. SF36 PF = SF36 physical function sub-scale score. HADS = Hospital Anxiety Depression Scale. PHQ-15 = Patient Health Questionnaire. ¶Last seven lines show means (SD). $The comparisons were by one way ANOVA across the centre strata of low, medium and high NSAE counts, with linear test for trend.