Table.
Antibody Titers Measured Using Serial Dilutions of Serum or Cerebrospinal Fluid and Cell-Based Assay
| Time After Hospital Admission, mo | Summary of All Treatment Modalities and Antibody Titers | Serum Antibodya | CSF Antibodya |
|---|---|---|---|
| 1 | Diagnostic lumbar puncture | 1:102 400 | 1:10 240 |
| 1.5 | Teratoma resection and oophorectomy | ||
| 2 | IVIg | ||
| 2 | Methylprednisolone | ||
| 2–3 | Rituximab | ||
| 4 | Diagnostic lumbar puncture | 1:51 200 | 1:5120 |
| 6, 7, and 8 | Cyclophosphamide | ||
| 8–9 | Rituximab | ||
| 10 | Diagnostic lumbar puncture | 1:25 600 | 1:2560 |
| 11 | Cyclophosphamide | ||
| 12 | Plasmapheresis | ||
| 12 | Diagnostic lumbar puncture | 1:51 200 | 1:5120 |
| 13–16 | Intravenous high-dose methotrexate | ||
| 16 | Rituximab | ||
| 16 | Diagnostic lumbar puncture | 1:25 600 | 1:5120 |
| 18 | Electroconvulsive shock | ||
| 20 | Cyclophosphamide | ||
| 20 | IVIg | ||
| 22 | Cyclophosphamide | ||
| 22 | IVIg |
Abbreviations: CSF, cerebrospinal fluid; IVIg, intravenous immunoglobulin.
a
Antibody titers were determined using serial dilutions of serum and CSF on rat brain tissue and human embryonic kidney cells expressing NR1 subunits of the N-methyl-D-aspartate receptor. The titer reflects the highest dilution at which reactivity was visible.