Table 2.
Clinical (A) and laboratory (B) toxicity noted in study patients by category and grade.
| A. | |||||
|---|---|---|---|---|---|
| Body System | Toxicity Grades (NCI CTC V.3) | Total Occurrences | |||
| 1 | 2 | 3 | 4 | ||
| Constitutional | 8 | 2 | 2 | 0 | 12 |
| Dermatology/Skin | 1 | 0 | 0 | 0 | 1 |
| Gastrointestinal | 11 | 4 | 6 | 0 | 21 |
| Infection | 5 | 0 | 0 | 1 | 6 |
| Lymphatics | 4 | 1 | 0 | 0 | 5 |
| Musculoskeletal | 1 | 0 | 0 | 0 | 1 |
| Neurology | 3 | 0 | 0 | 0 | 3 |
| Pain | 25 | 20 | 1 | 0 | 46 |
| Respiratory | 2 | 2 | 0 | 2 | 6 |
| Renal/Genitourinary | 0 | 0 | 2 | 0 | 2 |
| Syndromes | 3 | 0 | 0 | 0 | 3 |
| Vascular | 0 | 0 | 0 | 1 | 1 |
| Total | 63 | 29 | 11 | 4 | 107 |
| B. | |||||
|---|---|---|---|---|---|
| Lab Tests | Toxicity Grades (NCI CTC V.3) | Total Occurrences | |||
| 1 | 2 | 3 | 4 | ||
| Anemia | 18 | 10 | 4 | 0 | 32 |
| Hyperglycemia | 0 | 1 | 0 | 0 | 1 |
| Hyperkalemia | 1 | 0 | 1 | 0 | 2 |
| Elevated Creatinine | 3 | 2 | 1 | 0 | 6 |
| Neutropenia | 9 | 3 | 0 | 0 | 12 |
| Hypocalcemia | 0 | 1 | 0 | 0 | 1 |
| Thrombocytopenia | 7 | 0 | 0 | 0 | 7 |
| Elevated PTT | 2 | 0 | 1 | 0 | 3 |
| Elevated INR | 0 | 0 | 1 | 0 | 1 |
| Total | 40 | 17 | 8 | 0 | 65 |