Table 3.
Neonatal Cerebral White Matter Abnormalities and Risk of Persistent Attention/Hyperactivity Problems among Very Preterm Born Children
| Neonatal Cerebral White Matter Abnormality | Attention/Hyperactivity Problem, Age 4 to 9 Years, %
|
p | |
|---|---|---|---|
| None/Transient (N=85) | Persistent (N=13) | ||
| White matter abnormality | |||
| None | 21.2 | 15.4 | |
| Mild | 62.4 | 53.8 | |
| Moderate–severe | 16.5 | 30.8 | .34 |
| White matter signal abnormality | |||
| Normal | 45.9 | 30.8 | |
| Focal (≤2 regions) | 40.0 | 46.2 | |
| Extensive (≥2 regions) | 14.1 | 23.1 | .30 |
| Periventricular white matter volume loss | |||
| Normal | 52.9 | 38.5 | |
| Mild–moderate | 41.2 | 46.2 | |
| Diffuse | 5.9 | 15.4 | .24 |
| Cystic abnormality | |||
| Normal | 86.2 | 84.6 | |
| Focal (single, <2mm) | 9.4 | 7.7 | |
| Extensive (multiple, ≥2mm) | 2.4 | 7.7 | .50 |
| Ventricular dilatation | |||
| Normal | 38.8 | 30.8 | |
| Mild–moderate | 45.9 | 53.8 | |
| Marked | 15.3 | 15.4 | .83 |
| Thinning of the corpus callosum | |||
| Normal | 27.1 | 15.4 | |
| Focal | 58.8 | 76.9 | |
| Global | 14.1 | 7.7 | .81 |
Note. Reported associations persisted after adjustment for postmenstrual age at MRI, sex, and family socioeconomic status.