Table 4.
Neonatal Global Cerebral Tissue Volumes and Risk of Persistent Attention/Hyperactivity Problems
| Neonatal Global Cerebral Tissue Volume, M ± SD | Attention/Hyperactivity Problem, Age 4 to 9 Years
|
p
|
||||
|---|---|---|---|---|---|---|
| None (1) | None/Transient (2) | Persistent (3) | Overall | (1) vs. (3) | (2) vs. (3) | |
|
| ||||||
| Full-Term (N=6) | Very Preterm (N=67) | Very Preterm (N=13) | ||||
| Total cerebral tissue | ||||||
| Absolute volume, ml | 441.4 ± 25.2 | 410.1 ± 49.9 | 404.2 ± 39.6 | .12 | .12 | .68 |
| Relative percentage within intracranial cavity | 94.6 ± 2.6 | 91.0 ± 4.0 | 87.8 ± 4.9 | .001 | .001 | .01 |
| Cortical gray matter | ||||||
| Absolute volume, ml | 193.4 ± 27.1 | 177.9 ± 38.3 | 176.5 ± 33.2 | .36 | .36 | .90 |
| Relative percentage within intracranial cavity | 41.5 ± 5.9 | 39.3 ± 6.6 | 38.4 ± 6.4 | .33 | .33 | .64 |
| Subcortical gray matter | ||||||
| Absolute volume, ml | 12.3 ± 3.0 | 12.6 ± 4.2 | 12.3 ± 3.5 | 1.0 | 1.0 | .82 |
| Relative percentage within intracranial cavity | 2.6 ± 0.6 | 2.8 ± 0.9 | 2.7 ± 0.7 | .94 | .94 | .64 |
| Myelinated white matter | ||||||
| Absolute volume, ml | 17.8 ± 8.2 | 13.4 ± 5.7 | 12.9 ± 5.4 | .09 | .09 | .74 |
| Relative percentage within intracranial cavity | 3.8 ± 1.6 | 3.0 ± 1.2 | 2.8 ± 1.2 | .11 | .11 | .67 |
| Unmyelinated white matter | ||||||
| Absolute volume, ml | 218.0 ± 26.2 | 206.2 ± 31.8 | 202.5 ± 31.5 | .32 | .32 | .70 |
| Relative percentage within intracranial cavity | 46.7 ± 5.1 | 45.9 ± 6.0 | 43.9 ± 5.6 | .34 | .34 | .28 |
| Cerebrospinal fluid | ||||||
| Absolute volume, ml | 25.1 ± 12.7 | 41.0 ± 19.4 | 57.7 ± 26.5 | .002 | .002 | .008 |
| Relative percentage within intracranial cavity | 5.4 ± 2.6 | 9.0 ± 4.0 | 12.2 ± 4.9 | .001 | .001 | .01 |
Note. Reported associations persisted after adjustment for postmenstrual age at MRI, sex, and family socioeconomic status.