Table 3.

Measures of Test Performance Characteristics

	Optimal Cut Point	Proportion Over Cut Point with ATN	AUC (95% CI)	Validation AUC*
Tubular injury markers
NGAL (ng/ml)	365	25/35 (71%)	0.78 (0.69–0.88)	0.787
IL-18 (pg/ml)	85	21/33 (64%)	0.71 (0.61–0.81)	0.711
KIM-1 (ng/ml)	15.4	15/24 (63%)	0.64 (0.53–0.75)	0.639
L-FABP (ng/ml)	25	21/30 (70%)	0.69 (0.57–0.80)	0.688
Tubular function marker
FENa (%)	0.1	22/62 (35%)	0.56 (0.45–0.68)	0.563
Glomerular injury marker
Albumin (mg/dL)	44	29/52 (56%)	0.73 (0.64–0.83)	0.734

Abbreviations: ATN, acute tubular necrosis; AUC, area under the curve; CI, confidence interval; NGAL, neutrophil gelatinase associated lipocalin; IL-18, interleukin-18; KIM-1, kidney injury molecule-1; L-FABP, liver-type fatty acid binding protein; FENa, fractional excretion of sodium

^*Validation AUCs derived from leave-10-out cross validation performed with SAS Proc Surveyselect