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. Author manuscript; available in PMC: 2015 Jul 1.
Published in final edited form as: J Hepatol. 2014 Mar 5;61(1):139–147. doi: 10.1016/j.jhep.2014.02.021

Fig. 4. Diet-induced NASH and human NASH causes altered expression of OATP transporters.

Fig. 4

mRNA and protein expression of Oatp1a1 (A), Oatp1a4 (B), Oatp1b2 (C), and Oatp2b1 (D). Representative western blots and the Two-way ANOVA p-values are shown. *indicates a p-value <0.05 according to a Two-way ANOVA Bonferroni multiple comparison post-test. Data represent mean ± SEM. WT control n=4, WT NASH n=4, Slco1b2−/− control n=4, Slco1b2−/− NASH n=4. (E) OATP1B1, OATP1B3, and OATP2B1 mRNA expression levels in normal (n=20), steatosis (n=10), and NASH (n=19) livers. (F) OATP1B1, OATP1B3, and OATP2B1 protein expression levels in normal (n=10), steatosis (n=4), and NASH (n=12) livers. Box and whisker plots represent the median and the min and max. *indicates a p-value <0.05 according to a One-way ANOVA Dunnett’s multiple comparison post-test. Representative human OATP blots are shown on the right.