Table 2.

List of drug loaded nonionic surfactants vesicles in ocular delivery.

Surfactant	Drug loaded	Comments	References
Brij 35, 78, 98, and 700	Atenolol, timolol, betaxolol cyclosporine A	Significantly increased the corneal permeability. Significantly increased bioavailability of ophthalmic drugs by using contact lenses.	[52, 76]
Polysorbate 80, polyoxyl 40 stearate, and polyoxyl 60 hydrogenated castor oil	Cyclosporine A	Improve ocular CsA penetration and are clinically useful in the treatment of immune-mediated ophthalmic diseases.	[71]
Pluronic F127	Pilocarpine	Enhanced miotic response to a single instillation of pilocarpine eye drops compared to an aqueous solution of the drug.	[68]
Polysorbates 60 and 80 and Brij 35	Gentamicin sulphate	Effective in the prolongation of drug release from the ocular delivery and observed no irritancy on albino rabbits.	[72]
Polysorbate 20	Cyclopentolate	Promoted ocular absorption.	[23, 25]
Solulan C-24 and span 60	Timolol maleate	Treatment of ocular hypotensive activity. Exhibited sustained controlled ocular drug delivery.	[45, 46]
Spans 20, 40, 60, and 80	Acyclovir	Effective for the treatment of herpes simplex keratitis.	[67]
	Acetazolamide	Effective in enhancing the bioavailability of drug and lowered the intraocular pressure.	[43, 45, 73]
	Brimonidine tartrate	Improved bioavailability and increased precorneal residence time. Decreased the intraocular pressure for a prolonged period of time and nonirritant effect	[77–80]
	Naltrexone hydrochloride	Possessed better ocular tolerability and less ocular irritation.	[74]
	Fluconazole	Improved permeability as compared to marketed formulation and nonirritant effect.	[25]
	Flupirtine maleate	Improved the low corneal permeability for effective management of trigeminal neuralgia.	[75]
	Diclofenac sodium	Nonirritant and safe vesicular system for the effective ocular drug delivery.	[68]
	Levofloxacin.	Efficient in prolonging the drug release with reduced side effects.	[69]