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Superimposition of the crystal structures of mTS-dUMP (green) and mTS-dUMP-Raltitrexed (violet) complexes. Side chains of selected, mostly hydrophobic, amino acid residues located between the N-terminus and active site are shown as sticks and ligands, dUMP and Raltitrexed, as ball and sticks. N-terminal amino acids in the tertiary complex have no equivalents in the binary complex, as this part was disordered in the latter structure.
