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. Author manuscript; available in PMC: 2015 Jul 1.
Published in final edited form as: J Immunol. 2014 May 21;193(1):177–184. doi: 10.4049/jimmunol.1400553

Figure 3. Neonatal CD8+ T cells exhibit a more differentiated phenotype.

Figure 3

(A) Splenocytes were harvested at indicated days post infection and donor CD8+ T cells from congenically marked adult (shaded) and neonatal (line) were assessed for surface expression of CD127, KLRG1, CD62L and CD27. Histograms show representative data from each timepoint. (B) Statistical analysis of phenotypic markers over all recipient mice on day 7 post infection. (C) IFNγ production was assayed by peptide re-stimulation of splenocytes on indicated days post infection. Histograms show representative data from each timpoint. Significance was determined by paired T test. Data representative of 4 experiments, n=4−8 mice/group.