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. Author manuscript; available in PMC: 2015 Jul 1.
Published in final edited form as: J Immunol. 2014 May 21;193(1):177–184. doi: 10.4049/jimmunol.1400553

Figure 6. Failure to form CD8+ memory is a general feature of neonatal CD8+ mediated immune responses.

Figure 6

1×104 gBT-I CD8+ T cells from both adult and neonatal donors were co-transferred intravenously to congenic, wild type recipients. These recipients were then infected intraperitoneally with 2×105 PFU VACV-gB. Recipient mice were serially bled to monitor donor specific CD8+ T cell responses. (A) Percentage of gBT-1 CD8+ T cell in donor adult (solid) or neonatal (dashed) cells following infection and subsequent intravenous challenge with WT Lm gB (5×104 CFU). (B) The ratio of the donor populations with respect to time indicates that adult donors become the majority population. (C) Phenotypic distribution of adult and neonatal donors at peak of primary response (day 6). Significance was determined by paired T test. Data are representative of 2 experiments, n=8–12.