Table 3.
Multivariate analysis: Secreted cytokines by asthma phenotype1
| Adjusted2 OR for higher cytokine MFI3 | ||||||
|---|---|---|---|---|---|---|
| No Asthma N=385 GM (95% CI) | Allergic Asthma N=90 GM (95% CI) | Non-Allergic Asthma N=28 GM (95% CI) | Allergic Asthma vs No Asthma | Non-Allergic Asthma vs No Asthma | Allergic Asthma vs Non- Allergic Asthma | |
| Th17 cytokine | ||||||
| IL17A | 243 (215, 274) | 231 (179, 297) | 299 (206, 435) | 0.8 (0.5–1.1) | 1.1 (0.6–1.8) | 0.7 (0.4–1.3) |
| IL17F | 104 (94, 115) | 116 (91, 147) | 120 (87, 166) | 1.1 (0.9–1.4) | 1.2 (0.8–1.8) | 1.0 (0.6–1.5) |
| IL22 | 673 (606, 747) | 726 (593, 888) | 773 (570, 1048) | 1.4 (0.9–2.0) | 1.0 (0.6–1.7) | 1.4 (0.7–2.6) |
| Treg associated cytokine | ||||||
| IL10 | 14.2 (12.9, 15.6) | 15.4 (12.4, 19.0) | 13.5 (10.2, 17.9) | 1.2 (0.8–1.8) | 0.7 (0.4–1.4) | 1.6 (0.8–3.4) |
| Th2 cytokine | ||||||
| IL4 | 15.9 (14.7, 17.2) | 18.2 (15.3, 21.5) | 16.4 (12.8, 21.1) | 0.9 (0.4–1.7) | 1.4 (0.5–4.0) | 0.6 (0.2–2.0) |
| IL5 | 21.4 (19.4, 23.6) | 28.3 (23.2, 34.5) | 21.1 (15.3, 29.1) | 2.3 (1.3–3.8)** | 0.8 (0.3–1.8) | 2.9 (1.1–7.3)* |
| IL13 | 48.5 (44.1, 53.3) | 54.5 (44.5, 66.6) | 48.5 (44.1, 53.3) | 0.8 (0.5–1.4) | 0.6 (0.2–1.4) | 1.4 (0.5–3.7) |
| Th1 cytokine | ||||||
| IFNγ | 270 (245, 297) | 251 (204, 308) | 364 (282, 469) | 0.6 (0.4–1.0)* | 2.5 (1.2–5.1)** | 0.3 (0.1–0.6)* |
| IL12 | 4.8 (4.7, 5.0) | 4.6 (4.3, 5.0) | 4.8 (4.3, 5.4) | 0.5 (0.3–1.2) | 0.8 (0.2–2.7) | 0.7 (0.2–3.8) |
1
cytokine variables were log-transformed prior to inclusion in the regression model; sample size reduced due to inclusion of IL12 in multivariable model
2
adjusted for all other cytokines in table
3
mean fluorescence intensity
**
p <0.01;
*
p <0.05