Table 2.

Safety and Hemodynamic Data from Echocardiography

	Non-Ischemic (n=3)				Ischemic (n=4)
	Pre MB 1 (30min)	Post MB 1 (40min)	Pre MB 2 (90min)	Post MB 2 (100min)	Baseline	Pre MB 1 (30min)	Post MB 1 (40min)	Pre MB 2 (90min)	Post MB 2 (100min)
CO (L/min)	1.2±0.3	1.3±0.2	1.4±0.2	1.1±0.2	1.3±0.1	0.9± 0.2*	0.9±0.2*	0.9±0.1*	0.8±0.1*
SV (ml)	9.9± 1.5	10.5±1.1	10.5±0.9	9.3±2.5	11.4±1.7	9.5±2.3	10.1±2.3	8.6±0.2	8.4±0.6*
LVEF (%)	55±2.5	56±4.9	59±5.3	60±1.6	68±5.5	63±5.7	61±1.9	64±0.3	65±1.3
LVIDs (ml)	5.1±1.2	5.2±1.8	4.4±0.9	4.5±0.4	3.8±1.1	5.0±1.4	5.2±0.9	3.4±0.5	3.5±0.3
LVIDd (ml)	11.5±2.1	11.6±3.1	10.8±1.6	11.4±1.1	11.8±2.0	13.3±2.8	13.3±2.2	9.2±1.5	10.2±1.4
PASP (mm Hg)	12.6±2.3	12.8±1.2	13.6±2.3	12.2±3.8	17.6±2.4	18.9±0.8	19.1±0.1	NM	17.5±0.8
PVRI-1	10.7±2.4	10.5±1.9	9.0±0.7	10.5±1.3	13.3±1.9	16.2±0.2	18.2±1.2£	NM	21±0.1£
PVRI-2	6.6±2.2	6.1±2.3	5.8±0.9	6.2±2.9	7.2±1.8	9.8±5.1	12.4±5.9	NM	9.1±1.3
Mitral E/A	1.9±0.3	2.0±0.6	1.4±0.2	1.8±0.7	2.0±0.5	1.9±0.8	2.0±0.5	2.0±0.5	2.0±1.1
Mitral E′ (cm/s)	12.5±2.9	11.5±2.7	10.8±0.4	11.7±1.6	11.2±1.5	8.8±2.1	9.7±2.0	7.4±3.0*	7.0±1.8*
Mitral S′ (cm/s)	10.4±1.6	9.1±1.6	11.6±3.5	9.7±1.4	10.7±1.5	6.2±3.4*	7.0±1.4*	5.4±1.5*	5.7±0.4*
Mitral E/E′	4.8±1.2	5.6±2.5	5.5±1.4	5.2±2.5	7.9±2.3	8.8±2.3	7.5±1.8	7.0±1.8	9.9±0.6
TAPSE (cm)	0.58±0.03	0.60±0.05	0.64±0.09	0.62±0.06	1.03±0.11	1.02±0.11	1.02±0.11	0.99±0.08	0.94±0.05
Tricuspid S′ (cm/s)	10.8±2.9	10.4±3.3	12.5±3.8	7.9±1.0	8.1±1.7	5.8±2.1	6.7±1.3	5.2±1.4	7.3±5.3

CO, cardiac output; E′, peak early diastolic annular velocity; LVIDd, left ventricular internal diameter at end-diastole LVIDs, left ventricular internal diameter at end-systole; MB, microbubble; NM, not measuared; PASP, pulmonary artery systolic pressure; PVRI, pulmonary vascular resistance index; S′, peak systolic annular velocity; SV, stroke volume; TAPSE, tricuspid annular plane systolic excursion;

^*p<0.05 vs. baseline