Fig. 2.

Changes in brain temperature after initiation of therapeutic hypothermia using the cooling pad. (A) Hemicraniectomized beagle brain was covered with the polyethylene cooling pad (approximately 5 cm×5 cm). To monitor brain temperature, a thermocouple was implanted in the middle of cooling area. The cold saline (4~10℃) was infused into the cooling pad, which was connected to a circulating system. (B) After initiation of cooling (ON), the temperatures of the surface of the brain and the targeted brain area (10 mm below the surface) were ~27℃ and ~ 33℃, respectively; thus, indicating that hypothermia was rapidly induced. In the subsequent rewarming (OFF) and cooling periods (ON), the surface and targeted brain area temperatures were maintained at 31~33℃ and 35~37℃, respectively.