Skip to main content
. Author manuscript; available in PMC: 2015 Jul 1.
Published in final edited form as: Arterioscler Thromb Vasc Biol. 2014 May 8;34(7):1514–1521. doi: 10.1161/ATVBAHA.114.303746

Figure 6. 14-3-3zeta protein levels are reduced and cofilin is hyperactivated in blood monocytes from dyslipidemic atherosclerosis-prone mice.

Figure 6

Blood monocytes were isolated and purified from LDL receptor-deficient mice that were fed for 10 weeks either a low fat diet (LFD) or a high fat diet (HFD). (A) 14-3-3zeta levels were determined by Western blot analysis (n=5). (B) MCP-1-induced cofilin phosphorylation was assessed by Western blot analysis (n=4). (C) Hypothetical model for the hyper-activation of cofilin in metabolically primed monocytes.