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The change in the VAS of heartburn (ITT population)
| Unit: cm | Topaal Mean (SE) | Nacid Mean (SE) | Difference | P |
| Visit 1/baseline Observed data | 7.52 (0.42) | 7.43 (0.45) | 0.09 | 0.8774 |
| Visit 3/week 7Observed data | 1.15 (0.30) | 3.06 (0.34) | –1.91 | < 0.0001 |
| Change from baseline | –6.39 (0.28) | –4.44 (0.31) | –1.95 | < 0.0001 |
ANCOVA model: Dependent variable = (baseline value) + treatment.
