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. 2006 Feb 14;12(6):885–895. doi: 10.3748/wjg.v12.i6.885

Figure 10.

Figure 10

H+ and HCO3 transport mechanisms in CFPAC-1 human pancreatic duct cells. The basolateral membrane expresses Na+/HCO3 co-transporters, Na+/H+ exchangers and Cl/HCO3 exchangers plus an unidentified Na+-independent HCO3 entry pathway. These transporters facilitate the rapid flux of HCO3 ions into the cell. K+ channels are also likely to be expressed on the basolateral membrane because altering extracellular K+ concentration affects HCO3 influx. The apical membrane expresses Na+/H+ exchangers, but not CFTR and Cl/HCO3 exchangers found in normal pancreatic duct cells. The apical membrane is an effective barrier to HCO3 influx from the lumen, but is freely permeable to CO2. CA: Carbonic anhydrase.