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. 2006 Feb 14;12(6):885–895. doi: 10.3748/wjg.v12.i6.885

Figure 5.

Figure 5

Basolateral HCO3– uptake – effects of H2-DIDS, acetazolamide and varying extracellular K+ concentration. The figure shows representative pHi traces. A: The anion transport inhibitor 600 µmol/L H2-DIDS (added to the basolateral membrane of cells for 2 min before and during the administration of basolateral HCO3–/CO2, dashed line, n=6) significantly decreased the extent of alkalinization (∆pHi) and rate of J(B) (n=6); B: Varying extracellular [K+] caused significant differences in ∆pHi and J(B) (n=9–11); C: The application of the membrane-permeable carbonic anhydrase inhibitor acetazolamide (100 µmol/L, n = 6) significantly decreased the overall ∆pHi and J(B). HS: HEPES.