Figure 2.

EGFR staining in the sections from different stages of BE along with the sections from normal squamous and CLE nondetectable BE. A: Squamous epithelium (SE); B: Nondetectable BE in CLE (NB); C: Specialized intestinal metaplasia (SIM); D: Indeterminate/low-grade dysplasia (I/LGD); E: high-grade dysplasia (HGD); F: Esophageal adenocarcinoma (EAC). Strong EGFR staining was detected in ACP cells (arrowhead) in the histological stages of SIM, I/LGD, HGD and EAC. A weak EGFR staining was found in NCP cells (arrow) and in the normal squamous epithelium.