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. Author manuscript; available in PMC: 2014 Dec 19.
Published in final edited form as: Nat Commun. 2014 Jun 19;5:4099. doi: 10.1038/ncomms5099

Figure 10. A revised model of adipocyte origins based on Pax3-Cre and Myf5-Cre lineage tracing to mature adipocytes.

Figure 10

Embryonic precursors expressing Pax3-Cre and Myf5-Cre give rise to a subset of APCs and mature brown and white adipocytes. A subset of brown and white adipocytes also arises from Pax3-Cre+ precursors that do not express Myf5-Cre. The origin of Pax3-Cre and Myf5-Cre negative adipocytes is not yet clear. Dotted lines are used to indicate lineages because the intermediate stages are poorly understood. Note that the knock-in Cre drivers used in this study are indicative of the activity of the endogenous promoters.