Table 3.

Fasting insulin and glucose association meta-analyses of multivariate rare variants SKAT tests at five genes at the chromosome 11p11.2 locus in the CHARGE Targeted Sequencing Study

	Fasting Insulin		Fasting Glucose
	All	Predictions 1-3	All	Predictions 1-3
ACP2	0.91	0.93	0.10	0.57
NR1H3	2.73 × 10−3	1.28 × 10−3	0.73	0.08
NR1H3 Conditioned on   GWAS variants *	0.08	1.71 × 10−3
MADD	0.73	0.83	0.73	0.95
MYBPC3	0.69	-	0.26	-
SPI1	0.23	0.51	0.7	0.24

P-values from meta-analysis of multivariate SKAT analyses for fasting insulin and fasting glucose from three cohort samples. Included are results from all rare variants and the subset of variants with prediction scores between 1 and 3 obtained from RegulomeDB.¹² Variants with these prediction scores were predicted to be any (or a combination) of the following: transcription factor binding site, transcription factor motif, DNase Footprint and/or DNase peak.

^*NR1H3 Fasting Insulin analyses were conditioning on GWAS variants rs7944584 and rs10838687 to access if known common variants explain (at least in part) the observed rare variant association.

Significance level: α = < 0.05/20 = 0.0025 (2.5 × 10⁻³)